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Updated: Feb 8, 2026

Measuring Endoreduplication by Flow Cytometry of Isolated Tuber Protoplasts
Published on: March 9, 2018
Regulation of feeding by somatostatin neurons in the tuberal nucleus
Sarah Xinwei Luo1, Ju Huang2, Qin Li1,3
1Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), Singapore 138667.
Abstract:
The tuberal nucleus (TN) is a surprisingly understudied brain region. We found that somatostatin (SST) neurons in the TN, which is known to exhibit pathological or cytological changes in human neurodegenerative diseases, play a crucial role in regulating feeding in mice. GABAergic tuberal SST (TNSST) neurons were activated by hunger and by the hunger hormone, ghrelin. Activation of TNSST neurons promoted feeding, whereas inhibition reduced it via projections to the paraventricular nucleus and bed nucleus of the stria terminalis. Ablation of TNSST neurons reduced body weight gain and food intake. These findings reveal a previously unknown mechanism of feeding regulation that operates through orexigenic TNSST neurons, providing a new perspective for understanding appetite changes.
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