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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
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Brain Perfusion Measurements Using Multidelay Arterial Spin-Labeling Are Systematically Biased by the Number of

M van der Thiel1,2, C Rodriguez3, P Giannakopoulos1,3

  • 1From the Faculty of Medicine of the University of Geneva (M.v.d.T., P.G., N.G., D.v.d.V., S.H.), Geneva, Switzerland.

AJNR. American Journal of Neuroradiology
|July 7, 2018
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Summary

Multidelay arterial spin-labeling (ASL) imaging parameters impact cerebral blood flow (CBF) estimates. More delays in ASL sequences lead to higher CBF values, highlighting the need for standardized acquisition.

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Area of Science:

  • Neuroimaging
  • Medical Physics

Background:

  • Multidelay arterial spin-labeling (ASL) is an emerging clinical neuroimaging technique.
  • The influence of imaging parameters on cerebral blood flow (CBF) estimation in multidelay ASL is not well understood.

Purpose of the Study:

  • To directly compare 3-delay and 7-delay multidelay ASL sequences.
  • To assess the impact of sequence parameters on estimated transit time and CBF.

Main Methods:

  • 87 healthy controls underwent 3-delay and 7-delay ASL scans.
  • Voxelwise comparisons of transit time-uncorrected and corrected CBF maps were performed.
  • Average CBF was calculated in specific brain regions.

Main Results:

  • The 7-delay sequence yielded higher CBF values than the 3-delay sequence in watershed areas.
  • Transit time estimations varied between sequences, with longer delays in peripheral regions for the 3-delay sequence.
  • The 7-delay sequence demonstrated lower hemispheric asymmetry.

Conclusions:

  • Standardization of acquisition parameters in multidelay ASL is necessary.
  • Imaging parameters, specifically the number of delays, significantly affect CBF quantification.
  • Sequences with more delays result in higher estimated CBF values.