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Development of Dermal Films Containing Miconazole Nitrate
Magdalena Bîrsan1, Mihai Apostu2, Nicoleta Todoran3
1Faculty of Pharmacy, "Grigore T. Popa", University of Medicine and Pharmacy of Iași, Iași 700115, Romania. magdalena.birsan@umfiasi.ro.
Molecules (Basel, Switzerland)
|July 7, 2018
Summary
New antifungal dermal films were developed using hydroxyethyl cellulose (HEC) and hydroxypropyl methylcellulose (HPMC) polymers. HEC-based films exhibited superior elasticity and drying capacity, with miconazole nitrate release up to 70%.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Dermatology
Background:
- Dermal films offer a promising drug delivery system for topical antifungal treatments.
- Optimizing film properties like mechanical strength and moisture handling is crucial for efficacy.
- Miconazole nitrate is a widely used antifungal agent requiring effective delivery systems.
Purpose of the Study:
- To develop and characterize novel antifungal dermal films incorporating miconazole nitrate.
- To evaluate the mechanical properties, moisture behavior, and in vitro drug release of the developed films.
- To compare the performance of films based on hydroxyethyl cellulose (HEC) and hydroxypropyl methylcellulose (HPMC) polymers.
Main Methods:
- Three polymeric dermal films were prepared using HEC and HPMC polymers with varying miconazole nitrate concentrations.
- Mechanical properties (elongation, adhesion) and moisture interactions (absorption, loss) were assessed.
- In vitro drug release of miconazole nitrate was evaluated using Franz diffusion cells with a synthetic membrane.
Main Results:
- HEC-based films demonstrated greater elasticity and superior drying capacity compared to HPMC films.
- Films exhibited translucency or shininess with controlled thickness and miconazole nitrate content.
- In vitro studies showed a miconazole nitrate release rate of up to 70% from the dermal films.
Conclusions:
- Hydroxyethyl cellulose (HEC) is a suitable polymer for developing elastic and efficient antifungal dermal films.
- The developed dermal films show potential for effective topical delivery of miconazole nitrate.
- Further research can optimize film formulations for enhanced antifungal therapy.
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