Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyphosphoinositides and cell activation.

P Marche

    Nouvelle Revue Francaise D'Hematologie
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This review explores inositol lipid metabolism, focusing on how polyphosphoinositides trigger platelet responses. It examines the link between phosphoinositide metabolism and intracellular calcium mobilization, crucial for these physiological reactions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neurovascular microcirculatory vasodilation mediated by C-fibers and Transient receptor potential vanilloid-type-1 channels (TRPV 1) is impaired in type 1 diabetes.

    Scientific reports·2017
    Same author

    Involvement of the ADAM 12 in thrombin-induced rat's VSMCs proliferation.

    Current medicinal chemistry·2011
    Same author

    Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2009
    Same author

    Insulin regulation of proliferation involves activation of AKT and ERK 1/2 signaling pathways in vascular smooth muscle cells.

    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2009
    Same author

    IRES complexity before IFN-alpha treatment and evolution of the viral load at the early stage of treatment in peripheral blood mononuclear cells from chronic hepatitis C patients.

    Journal of medical virology·2007
    Same author

    Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine.

    Arteriosclerosis, thrombosis, and vascular biology·2003
    Same journal

    XIVth Congress of the French Society of Hematology. Paris, France, February 3-4, 1995. Abstracts.

    Nouvelle revue francaise d'hematologie·1995
    Same journal

    Improved detection of CD2 on formaldehyde-fixed non dehydrated cells.

    Nouvelle revue francaise d'hematologie·1995
    Same journal

    Engraftment of CD34+ peripheral blood progenitor cells into multiple myeloma patients following total body irradiation.

    Nouvelle revue francaise d'hematologie·1995
    Same journal

    Allogeneic transplantation of peripheral blood progenitor cells.

    Nouvelle revue francaise d'hematologie·1995
    Same journal

    Selection and expansion of CD34+ cells.

    Nouvelle revue francaise d'hematologie·1995
    Same journal

    Ex vivo hematopoietic cell expansion: a theoretical and technological challenge.

    Nouvelle revue francaise d'hematologie·1995
    See all related articles

    Area of Science:

    • Biochemistry
    • Cellular Biology
    • Physiology

    Background:

    • Inositol-containing lipids play critical roles in cellular signaling pathways.
    • Platelet activation involves complex signaling cascades, including changes in intracellular calcium levels.

    Purpose of the Study:

    • To review the metabolism of inositol-containing lipids.
    • To elucidate the role of polyphosphoinositides in initiating platelet physiological responses.
    • To discuss the relationship between phosphoinositide metabolism and intracellular calcium mobilization.

    Main Methods:

    • Literature review of biochemical and cellular studies.
    • Analysis of signaling pathways involved in platelet activation.
    • Examination of the interplay between lipid metabolism and ion flux.

    Related Experiment Videos

    Main Results:

    • Polyphosphoinositides are key regulators of platelet activation.
    • Changes in phosphoinositide metabolism directly influence cytosolic calcium concentration.
    • This metabolic pathway is central to triggering essential platelet functions.

    Conclusions:

    • Phosphoinositide metabolism is integral to understanding platelet physiology.
    • The intricate relationship with calcium mobilization highlights a critical signaling nexus.
    • Further research into this pathway can reveal therapeutic targets for platelet disorders.