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Updated: Feb 8, 2026

Transfecting and Nucleofecting Human Induced Pluripotent Stem Cells
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Modelling microglial function with induced pluripotent stem cells: an update

Jennifer M Pocock1, Thomas M Piers2

  • 1Department of Neuroinflammation, University College London Institute of Neurology, London, UK. j.pocock@ucl.ac.uk.

Nature Reviews. Neuroscience
|July 7, 2018
PubMed

Insights

Microglia and macrophages are key immune cells in the central nervous system (CNS) and body. New methods using induced pluripotent stem cells are advancing the study and production of microglia for research.

Area of Science:

  • Neuroimmunology
  • Stem Cell Biology

Background:

  • Microglia, the resident immune cells of the central nervous system (CNS), and peripheral macrophages play critical roles in both health and disease.
  • Understanding these cells is crucial for developing treatments for neurological disorders.

Purpose of the Study:

  • To review recent advancements in the production of microglia using induced pluripotent stem cells (iPSCs).
  • To explore how these new methodologies will enhance future research on microglia.

Main Methods:

  • Discussion of recent technological progress in generating specific cell types from iPSCs.
  • Application of iPSC technology for microglia production.

Main Results:

  • Technological advances facilitate the generation of microglia from iPSCs.
  • This methodology offers new avenues for studying microglia.

Conclusions:

  • The development of iPSC-based methods for microglia production represents a significant step forward.
  • These advancements will greatly contribute to our understanding of microglia function in physiology and pathology.

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