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Updated: Feb 8, 2026
10:10
Reverse Total Shoulder Arthroplasty
Published on: July 5, 2011
44.0K
EFFICACY OF TRANEXAMIC ACID IN REDUCING BLOOD LOSS IN TOTAL KNEE ARTHROPLASTY
David Sadigursky1,2, Larissa Martins Araujo3, Rogério Jamil Carneiro Fernandes2
1. Faculdade de Tecnologia e Ciências de Salvador, Salvador, BA, Brazil.
Acta Ortopedica Brasileira
|July 7, 2018
Summary
Tranexamic acid effectively reduces blood loss and transfusion needs in total knee arthroplasty patients. This systematic review confirms its safety and efficacy compared to other antifibrinolytics.
Area of Science:
- Orthopedic Surgery
- Pharmacology
Background:
- Total knee arthroplasty (TKA) is associated with significant perioperative blood loss.
- Blood loss can lead to complications and increased transfusion rates.
Purpose of the Study:
- To evaluate the efficacy of tranexamic acid in minimizing blood loss during TKA.
- To assess the safety profile of tranexamic acid in this context.
Main Methods:
- Systematic literature review of randomized clinical trials (RCTs) published between 2000-2016.
- Searches conducted in PubMed, Science Direct, Google Scholar, and Lilacs.
- Inclusion of RCTs scoring >3 on the Jadad scale.
Main Results:
- Seven RCTs involving 948 patients met the inclusion criteria.
- Tranexamic acid demonstrated significant reduction in both perioperative and postoperative blood loss.
- No increase in adverse side effects was observed.
Conclusions:
- Tranexamic acid is a safe and effective agent for controlling bleeding in TKA.
- It offers superior blood loss reduction compared to other antifibrinolytics.
- Its use can decrease the need for blood transfusions post-TKA.
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