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Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice
Published on: January 7, 2019
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COULD OZONE TREATMENT BE A PROMISING ALTERNATIVE FOR OSTEOMYELITIS? AN EXPERIMENTAL STUDY
Ali Bilge1, Ömür Öztürk2, Yasemen Adali3
1. Department of Orthopedics and Traumatology, Kafkas University, Faculty of Medicine, Kars, Turkey.
Acta Ortopedica Brasileira
|July 7, 2018
Summary
Ozone treatment improved antioxidant capacity and reduced inflammation in a rat osteomyelitis model. This suggests ozone may be a beneficial adjunctive therapy for osteomyelitis.
Area of Science:
- Biochemistry
- Histopathology
- Experimental Medicine
Background:
- Osteomyelitis is a challenging bone infection requiring effective treatments.
- Investigating novel therapeutic approaches like ozone therapy is crucial.
Purpose of the Study:
- To evaluate the biochemical and histopathological effects of ozone treatment in a rat model of osteomyelitis.
Main Methods:
- Rats with induced osteomyelitis were treated with intraperitoneal ozone for 3 weeks.
- Biochemical markers (TAC, PCO, LDH) and histopathological features (inflammation, necrosis, abscess) were assessed.
Main Results:
- Ozone treatment significantly increased total antioxidant capacity (TAC) and decreased lactate dehydrogenase (LDH) levels.
- Histopathological analysis showed reduced osteomyelitis, inflammation, necrosis, and abscess formation in the ozone-treated group.
Conclusions:
- Ozone therapy demonstrates potential as an adjunctive treatment for osteomyelitis.
- Further research in human and animal models is warranted to confirm efficacy and establish treatment guidelines.
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