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Updated: Jan 11, 2026

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

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CXCR7 Targeting and Its Major Disease Relevance.

Chuan Wang¹, Weilin Chen², Jianzhong Shen¹

¹Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, United States.

Frontiers in Pharmacology

|July 7, 2018

Summary

The chemokine receptor CXCR7 (also known as ACKR3) acts as a scavenger or signaling receptor, with its function debated due to multiple ligands and biased signaling. Understanding these properties is key to resolving controversies surrounding CXCR7 activity.

Keywords:

ACKR3 CXCL12 CXCR7 SDF-1 biased signaling chemokine receptor

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Published on: March 10, 2018

Area of Science:

Pharmacology
Molecular Biology
Immunology

Background:

Chemokine receptors are crucial in physiological and pathological processes.
CXCR7 (ACKR3) is a non-classical seven-transmembrane receptor with debated signaling functions.
Existing research on CXCR7 has limitations, including a narrow focus on ligands and insufficient data on ligand- and tissue-specific signaling.

Purpose of the Study:

To review the endogenous and exogenous ligands of CXCR7.
To summarize diseases associated with CXCR7.
To discuss biased signaling events related to CXCR7.

Main Methods:

Literature review focusing on CXCR7 ligands, associated diseases, and signaling.
Analysis of existing research to identify sources of controversy.
Synthesis of data to explain conflicting opinions on CXCR7 function.

Main Results:

CXCR7 interacts with numerous natural ligands beyond SDF-1 and I-TAC.
Ligand and tissue bias significantly influences CXCR7 signaling.
Contradictory findings regarding CXCR7's signaling or scavenger role stem from these complexities.

Conclusions:

The diverse ligand interactions and biased signaling of CXCR7 contribute to the ongoing debate about its function.
Further research into CXCR7's pharmacologic properties is needed to clarify its role.
This review highlights new directions for studying CXCR7 biology and pharmacology.