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Updated: Feb 8, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
Notch Signaling and Immune Regulation in Alloimmunity
Naoka Murakami1, Ivan Maillard2,3, Leonardo V Riella1
1Transplantation Research Center, Renal Division, Brigham & Women's Hospital, Harvard Medical School, Boston, MA.
Abstract:
Notch signaling plays a pivotal role in the differentiation and fate determination of T cells, B cells, dendritic cells (DCs) and innate lymphoid cells (ILCs). Recent gene-targeting and antibody approaches advanced our knowledge of the importance of Notch signaling in fine-tuning the peripheral immune response. Here we review current knowledge of the Notch pathway, focusing on solid organ transplant and graft-versus-host disease preclinical models, and discuss the potential of targeting Notch to suppress the immune response and improve transplant outcomes.
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