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Updated: Feb 8, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
Multiple circular pleural metastases of renal cell carcinoma
Hisako Kushima1, Hiroshi Ishii1, Yoshiaki Kinoshita1,2
1Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, 814-0180, Japan.
Abstract:
A 91-year-old woman was admitted with persistent pyrexia, anorexia and weight loss. A chest radiograph showed multiple circular masses of various sizes. Chest computed tomography revealed multiple pleural tumors without any lung lesion. The ultrasound-guided biopsy specimens demonstrated diffusely-proliferated tumor cells with clear or vacuolated cytoplasm, which were positive for CD10, PAX8, vimentin and CAM5.2, but were negative for mesothelial cell markers such as HBME-1 and thrombomodulin. These findings indicated metastatic clear cell carcinoma of the kidney, and a solitary renal tumor was observed on abdominal computed tomography. It has been reported that pleural metastases constituted 12% of patients with progressive renal cell carcinoma, and most of the pleural metastases occurred secondary to lung metastasis. This was a rare case of renal cell carcinoma with an unusual chest image via an intriguing metastatic pathway, which was limited to pleura.
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