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Nanotechnology in retinal drug delivery
Sibo Jiang1, Yesenia L Franco1, Yan Zhou2
1Department of Pharmaceutics, University of Florida, Orlando, FL 32827, USA.
International Journal of Ophthalmology
|July 7, 2018
Summary
Nanotechnology offers promising solutions for retinal drug delivery, improving targeted and sustained treatment for conditions like age-related macular degeneration and diabetic retinopathy, addressing a key unmet need in ophthalmology.
Area of Science:
- Ophthalmology
- Nanotechnology
- Drug Delivery Systems
Background:
- Retinal diseases such as age-related macular degeneration (AMD) and diabetic retinopathy (DR) are primary causes of blindness in older adults.
- Current treatments aim to prevent vision loss, but efficient drug delivery to the posterior eye segment remains a challenge.
- Intravitreal injections are common but invasive, posing risks with repeated administration.
Purpose of the Study:
- To review the application of nanotechnology in delivering therapeutic agents to the retina.
- To explore advancements in retinal drug delivery systems from 2007 to 2017.
- To highlight nanotechnology's potential to overcome limitations of current ocular drug delivery methods.
Main Methods:
- Literature review of studies published between 2007 and 2017 via PubMed.
- Identification of research evaluating nanotechnology for posterior eye segment drug delivery.
- Analysis of various ocular drug delivery routes and nanosystems.
Main Results:
- Nanotechnology provides targeted and sustained delivery of therapeutic agents to the retina.
- Various nanosystems (hydrogels, liposomes, dendrimers, micelles) have been investigated.
- These systems are utilized across different delivery routes (intravitreal, periocular, subretinal, systemic).
Conclusions:
- Nanotechnology holds significant potential to revolutionize retinal drug delivery.
- It offers improved therapeutic efficacy and patient compliance for treating retinal diseases.
- Further research into nanosystems can address unmet needs in ophthalmic drug delivery.
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