Related Experiment Video
Updated: Feb 8, 2026
10:10
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
10.7K
Hydroxypropyl-β-Cyclodextrin and β-Cyclodextrin as Tablet Fillers for Direct Compression
Jaime Conceição1, Oluwatomide Adeoye2,3, Helena Maria Cabral-Marques2
1UCIBIO-ReQuimTe, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, n.° 228, 4050-313 Oporto, Porto, Portugal. jmgmconceicao@ff.up.pt.
AAPS Pharmscitech
|July 7, 2018
Summary
Hydroxypropyl-β-cyclodextrin and β-cyclodextrin show potential as direct compression tablet fillers. Hydroxypropyl-β-cyclodextrin offers superior compression properties and improved drug release compared to β-cyclodextrin, making it a viable alternative to lactose.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Cyclodextrins are versatile cyclic carbohydrates utilized as excipients in drug delivery.
- Their application as direct compression fillers requires thorough evaluation of physical and chemical properties.
Purpose of the Study:
- To assess the suitability of hydroxypropyl-β-cyclodextrin and β-cyclodextrin as tablet fillers for direct compression.
- To compare their performance against common pharmaceutical excipients.
Main Methods:
- Evaluation of flow properties (angle of repose, flow time, Carr index, Hausner ratio).
- Assessment of compaction behavior (energies, forces, plasticity index, lubrication efficiency).
- Analysis of carbamazepine release characteristics (dissolution rate, disintegration time).
Main Results:
- Both cyclodextrins demonstrated utility as direct compression fillers.
- Hydroxypropyl-β-cyclodextrin exhibited enhanced compression physics and superior drug release profiles over β-cyclodextrin.
- Lactose monohydrate and hydroxypropyl-β-cyclodextrin yielded the most favorable outcomes.
Conclusions:
- Cyclodextrins are effective tablet fillers for direct compression.
- Hydroxypropyl-β-cyclodextrin is a promising alternative to lactose, especially for lactose-intolerant patients, despite higher costs.
- The study highlights the potential of cyclodextrins in pharmaceutical formulations.
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