Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.6K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.6K
Adrenergic Receptors: β Subtype01:26

Adrenergic Receptors: β Subtype

3.8K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
3.8K
Antianginal Drugs: Nitrates and β-Blockers01:16

Antianginal Drugs: Nitrates and β-Blockers

1.6K
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
1.6K
Antihypertensive Drugs: Types of β-Blockers01:28

Antihypertensive Drugs: Types of β-Blockers

1.7K
β receptors are classified into three subclasses: β1, β2, and β3. β1 receptors are primarily located in the heart and kidneys. When they get activated, they increase heart rate, contractility, and renin release. This process enhances blood pressure and aids in stress management. In contrast, β2 receptors are situated mainly in the lungs, blood vessels, and skeletal muscles. Upon activation, they trigger smooth muscle relaxation, causing bronchodilation and...
1.7K
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

943
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
943
Esters to β-Ketoesters: Claisen Condensation Overview01:24

Esters to β-Ketoesters: Claisen Condensation Overview

4.2K
Regular Claisen condensation is a base-promoted reaction involving identical esters with two α hydrogens, condensing to produce β-ketoesters. It is a nucleophilic acyl substitution reaction wherein one of the ester molecules, upon deprotonation by the base, forms a nucleophilic enolate ion, while the other molecule serves as an electrophile.
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antibody-Drug Conjugates: Pharmacotherapeutic Properties and Future Perspectives.

Pharmaceutics·2026
Same author

Predictive value of the hERG assay for anticipating the arrhythmogenic potential of new drugs.

Drug discovery today·2026
Same author

Co-encapsulation in Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as an Emerging Therapeutic Strategy.

Molecular diagnosis & therapy·2026
Same author

Targeting Trypanothione Synthetase and Trypanothione Reductase: Development of Common Inhibitors to Tackle Trypanosomatid Disease.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Artificial intelligence in pharmacovigilance: a narrative review and practical experience with an expert-defined Bayesian network tool.

International journal of clinical pharmacy·2025
Same author

Enhancing Acute Migraine Treatment: Exploring Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for the Nose-to-Brain Route.

Pharmaceutics·2024

Related Experiment Video

Updated: Feb 8, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.7K

Hydroxypropyl-β-Cyclodextrin and β-Cyclodextrin as Tablet Fillers for Direct Compression.

Jaime Conceição1, Oluwatomide Adeoye2,3, Helena Maria Cabral-Marques2

  • 1UCIBIO-ReQuimTe, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, n.° 228, 4050-313 Oporto, Porto, Portugal. jmgmconceicao@ff.up.pt.

AAPS Pharmscitech
|July 7, 2018
PubMed
Summary

Hydroxypropyl-β-cyclodextrin and β-cyclodextrin show potential as direct compression tablet fillers. Hydroxypropyl-β-cyclodextrin offers superior compression properties and improved drug release compared to β-cyclodextrin, making it a viable alternative to lactose.

Keywords:
compactioncyclodextrinsdisintegrationdissolutionflow

More Related Videos

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

2.1K
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

14.4K

Related Experiment Videos

Last Updated: Feb 8, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.7K
Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

2.1K
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

14.4K

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Cyclodextrins are versatile cyclic carbohydrates utilized as excipients in drug delivery.
  • Their application as direct compression fillers requires thorough evaluation of physical and chemical properties.

Purpose of the Study:

  • To assess the suitability of hydroxypropyl-β-cyclodextrin and β-cyclodextrin as tablet fillers for direct compression.
  • To compare their performance against common pharmaceutical excipients.

Main Methods:

  • Evaluation of flow properties (angle of repose, flow time, Carr index, Hausner ratio).
  • Assessment of compaction behavior (energies, forces, plasticity index, lubrication efficiency).
  • Analysis of carbamazepine release characteristics (dissolution rate, disintegration time).

Main Results:

  • Both cyclodextrins demonstrated utility as direct compression fillers.
  • Hydroxypropyl-β-cyclodextrin exhibited enhanced compression physics and superior drug release profiles over β-cyclodextrin.
  • Lactose monohydrate and hydroxypropyl-β-cyclodextrin yielded the most favorable outcomes.

Conclusions:

  • Cyclodextrins are effective tablet fillers for direct compression.
  • Hydroxypropyl-β-cyclodextrin is a promising alternative to lactose, especially for lactose-intolerant patients, despite higher costs.
  • The study highlights the potential of cyclodextrins in pharmaceutical formulations.