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Myocardial Infarction and Functional Outcome Assessment in Pigs

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Published on: April 25, 2014

Testosterone, myocardial function, and mortality.

Vittorio Emanuele Bianchi¹

¹Clinical Center Stella Maris, Laboratory of Physiology of Exercise, Strada Rovereta 42, 47891, Falciano, Republic of San Marino. dott.vbianchi@gmail.com.

Heart Failure Reviews

|July 7, 2018

Summary

This summary is machine-generated.

Low testosterone levels increase cardiovascular disease (CVD) and mortality risk. However, testosterone therapy in hypogonadal individuals improves heart function, clinical outcomes, and survival, highlighting its beneficial role at physiological levels.

Keywords:

Cardiac mitochondria Cardiomyocytes Cardiovascular disease Cardiovascular mortality Coronary artery disease Heart failure Testosterone

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Area of Science:

Endocrinology
Cardiology
Molecular Biology

Background:

The cardiovascular system's sensitivity to androgens is established, yet the precise effects of testosterone on cardiac health remain debated.
Contrasting findings exist: anabolic abuse is linked to sudden cardiac death, while low testosterone correlates with increased cardiovascular disease (CVD) and mortality risk.

Purpose of the Study:

To review the impact of testosterone on myocardial function, coronary artery disease (CAD), and overall mortality.
To elucidate the role of testosterone in cardiovascular health and disease management.

Main Methods:

Systematic literature review and analysis of existing studies on testosterone's cardiovascular effects.
Evaluation of data concerning testosterone levels, myocardial tissue, CAD incidence, and mortality rates.

Main Results:

Low serum testosterone levels are significantly associated with a higher incidence of CAD and increased mortality.
Testosterone administration in hypogonadal elderly men and women demonstrated positive effects on cardiovascular function, clinical outcomes, and survival.
Physiological levels of testosterone appear safe and beneficial for myocardial function, impacting cellular and mitochondrial mechanisms.

Conclusions:

Testosterone plays a complex role in cardiovascular health, with low levels posing risks and physiological replacement offering benefits.
Androgen therapy requires careful consideration of dosage and individual patient factors, including interactions with estradiol.
Further research is needed to optimize androgen therapy strategies for cardiovascular disease (CVD) management.