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Differential prognostic impact of GELTAMO-IPI in cell of origin subtypes of Diffuse Large B Cell Lymphoma as defined

Carlos Montalbán1, Antonio Díaz-López2, Alejandro Martín3

  • 1Department of Haematology, MD Anderson Cancer Center, Madrid, Spain.

British Journal of Haematology
|July 7, 2018
PubMed

Insights

The Grupo Español de Linfomas y Trasplantes de Médula Ósea International Prognostic Index (GELTAMO-IPI) impacts diffuse large B cell lymphoma (DLBCL) survival differently based on cell of origin (COO) subtypes. GELTAMO-IPI identifies a poor prognosis group within the non-GCB subtype.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Diffuse large B cell lymphoma (DLBCL) is a heterogeneous non-Hodgkin lymphoma.
  • The Grupo Español de Linfomas y Trasplantes de Médula Ósea International Prognostic Index (GELTAMO-IPI) stratifies DLBCL patients into four risk groups.
  • DLBCL can be classified into Germinal Centre B (GCB) and non-GCB subtypes based on cell of origin (COO).

Purpose of the Study:

  • To investigate the differential impact of GELTAMO-IPI risk groups on survival across DLBCL subtypes (GCB vs. non-GCB).
  • To evaluate the interaction between GELTAMO-IPI and COO subtypes in predicting patient outcomes.

Main Methods:

  • A multivariate Cox regression model was employed.
  • The model included GELTAMO-IPI risk groups, COO subtypes (GCB/non-GCB), and their interaction term.
  • Analysis was performed on a cohort of 780 DLBCL patients with available GELTAMO-IPI and COO data.

Main Results:

  • A significant interaction (P=0.005) was observed between GELTAMO-IPI risk groups and COO subtypes.
  • In the GCB subtype, 5-year overall survival (OS) was 100% (LR), 75% (LIR), and 52% (HIR+HR).
  • In the non-GCB subtype, 5-year OS was 97% (LR), 82% (LIR+HIR), and 35% (HR), identifying a poor prognosis group.

Conclusions:

  • GELTAMO-IPI has a differential prognostic value in GCB and non-GCB DLBCL subtypes.
  • The GELTAMO-IPI effectively identifies a high-risk group with poor outcomes specifically within the non-GCB DLBCL subtype.
  • This highlights the importance of considering both prognostic indices and COO in DLBCL patient management.

Keywords:
GELTAMO-IPIHans algorithmcell of origin subtypingdiffuse large B cell lymphomaimmunohistochemistry

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