Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transgenic Organisms00:53

Transgenic Organisms

33.5K
Overview
33.5K
Understanding the Self01:28

Understanding the Self

309
The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...
309
Understanding Self-Concept01:20

Understanding Self-Concept

296
The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those...
296
Understanding Deception01:14

Understanding Deception

169
Deception is a pervasive aspect of human communication. Empirical studies have shown that most individuals engage in some form of deceit on a daily basis, with approximately 20% of social exchanges involving deceptive elements. Lying follows a developmental trajectory, peaking during adolescence and declining with age, possibly due to the maturation of cognitive control and social accountability.Cognitive and Social Factors in Deception DetectionDespite its prevalence, accurately detecting...
169
Understanding Love01:27

Understanding Love

194
Love, as a multifaceted psychological construct, encompasses emotions, cognitive processes, and behavioral patterns that play a crucial role in human relationships. It extends beyond attraction, manifesting in deep, enduring connections that influence personal well-being and social structures.Psychological Dimensions of LoveLove differs from friendship and mere liking through its depth and intensity. While friendship is built on mutual respect, trust, and companionship, love involves emotional...
194
Understanding Consciousness01:23

Understanding Consciousness

2.1K
Consciousness can be defined as the state of being aware of and able to think about one's existence, sensations, and surroundings. It encompasses two major components: awareness and arousal. Awareness pertains to the recognition of environmental stimuli and internal states. At the same time, arousal refers to the physiological readiness to engage with these stimuli, which varies significantly between states like sleep and wakefulness.
Sleep, a crucial state, is characterized by reduced...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Divergent temporal control of deltoid tuberosity and limb tendon development by an evolutionarily conserved scleraxis enhancer.

Development (Cambridge, England)·2026
Same author

3D polyurethane scaffolds for exploring osteogenic differentiation and mechanical stimulation of mesenchymal stromal cells.

Bone·2026
Same author

Functional impact of pathogenic mutations in the Runt homology domain of mouse Runx2 on skeletal and dental phenotypes in cleidocranial dysplasia.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2025
Same author

Giving It a Twist: One-Step Fabrication of Aligned Biomimetic Yarn Scaffolds via Rotational Melt Electrofibrillation.

Advanced healthcare materials·2025
Same author

Rotator Cuff Repair: Lessons from Immune Strategies, 3D Biofabrication and In Vivo Testing.

Cellular and molecular bioengineering·2025
Same author

Micropatterning and Nanodropletting of Titanium by Shifted Surface Laser Texturing Significantly Enhances In Vitro Osteogenesis of Healthy and Osteoporotic Mesenchymal Stromal Cells.

Journal of functional biomaterials·2025
Same journal

Inflammatory Preconditioning Reprograms Mesenchymal Stromal Cell-Derived Extracellular Vesicles into Distinct Functional States for Immunomodulation and Wound Healing.

Stem cells and development·2026
Same journal

Cancer Stem Cells as Dynamic Attractor States: Systems Biology of Tumor Plasticity and Therapy Resistance.

Stem cells and development·2026
Same journal

Evaluation of Puromycin-Induced Podocyte Injury and Protective Effects of Voclosporin Using Induced Pluripotent Stem Cells from a Patient with Nephrotic Syndrome Harboring an <i>INF2</i> Variant.

Stem cells and development·2026
Same journal

Simplified Derivation of Stable Early Passage Murine Embryonic and Parthenogenetic Stem Cells.

Stem cells and development·2026
Same journal

OCT3/4-Enhanced Dental Mesenchymal Stem Cells Acquire Hematopoietic Stem Cell-Like Properties and Support Hematopoietic Recovery in a Myelosuppressed Mouse Model.

Stem cells and development·2026
Same journal

Hematopoietic Stem Cell-Based Cell and Gene Therapy Beyond Monogenic Diseases.

Stem cells and development·2026
See all related articles

Related Experiment Video

Updated: Feb 8, 2026

Biomechanical Testing of Murine Tendons
10:09

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

14.1K

Understanding Tendons: Lessons from Transgenic Mouse Models.

Manuel Delgado Caceres1, Christian G Pfeifer1,2, Denitsa Docheva1,3

  • 11 Experimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Centre , Regensburg, Germany .

Stem Cells and Development
|July 7, 2018
PubMed
Summary
This summary is machine-generated.

Investigating tendon development, this review highlights that while most gene knockouts show mild effects, Scleraxis and TGFβ signaling loss cause severe tendon phenotypes. This underscores the complex, organized nature of tendon development and repair.

Keywords:
knockout micemice modelstendon and ligamentstendon biologytendon phenotypetransgenic technology

More Related Videos

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer
07:46

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

Published on: August 17, 2010

34.6K
Murine Flexor Tendon Injury and Repair Surgery
07:32

Murine Flexor Tendon Injury and Repair Surgery

Published on: September 19, 2016

13.7K

Related Experiment Videos

Last Updated: Feb 8, 2026

Biomechanical Testing of Murine Tendons
10:09

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

14.1K
In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer
07:46

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

Published on: August 17, 2010

34.6K
Murine Flexor Tendon Injury and Repair Surgery
07:32

Murine Flexor Tendon Injury and Repair Surgery

Published on: September 19, 2016

13.7K

Area of Science:

  • Musculoskeletal biology
  • Connective tissue research
  • Developmental genetics

Background:

  • Tendons and ligaments are vital musculoskeletal tissues, yet less studied than muscle or bone.
  • Key tendon-specific genes like Scleraxis, Mohawk, and Tenomodulin have been identified.
  • Understanding tendon ontogeny and signaling pathways is crucial for improving treatment of tendon degeneration.

Purpose of the Study:

  • To systematically review tendon-related genes and their characterization using knockout mouse models.
  • To analyze phenotypic changes in knockout mice to understand gene function in tendon development.
  • To identify critical genes and pathways for advancing tendon repair strategies.

Main Methods:

  • Systematic evaluation of publications on tendon-related genes.
  • Analysis of knockout (KO) and transgenic (Tg) mouse models.
  • Tabular reporting of gene functions and observed phenotypic changes.

Main Results:

  • Out of 24 studied genes, 22 knockout mouse models exhibited phenotypic changes.
  • Loss of Scleraxis and TGFβ signaling resulted in severe tendon developmental phenotypes.
  • Deficiencies in proteoglycans, Mohawk, EGR1/2, and Tenomodulin led to mild phenotypes, indicating compensatory mechanisms.

Conclusions:

  • Tendon development is a highly organized and robust system, with significant genetic redundancy, especially among proteoglycans.
  • Further identification of master tendon transcription factors is needed.
  • Enhanced understanding of tendon genetics will facilitate the development of targeted therapies for tendon disorders.