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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Stem Cell Culture in Microgravity and Its Application in Cell-Based Therapy.

Takeshi Imura1, Kei Nakagawa1, Yumi Kawahara2

  • 11 Division of Bio-Environmental Adaptation Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima, Japan.

Stem Cells and Development
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Microgravity research is advancing beyond astronaut health, showing promise for cell-based therapies. This review explores microgravity

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Area of Science:

  • Space science
  • Cell biology
  • Biomedical research

Background:

  • Space experiments have evolved from studying microgravity's effects on astronauts to utilizing microgravity for scientific applications.
  • Early research focused on mitigating adverse health effects of spaceflight.
  • Recent advancements highlight the potential of microgravity environments for diverse research objectives.

Purpose of the Study:

  • To review microgravity-induced cellular and molecular changes.
  • To summarize the applications of microgravity in cell-based therapy, particularly for central nervous system diseases.

Main Methods:

  • Analysis of data from space flight experiments.
  • Review of studies using simulated microgravity devices.
  • Examination of cellular and molecular responses to microgravity.

Main Results:

  • Microgravity influences cellular and molecular processes.
  • Protein crystallization and 3D cell culture are key applications.
  • Microgravity shows potential as a tool for cell-based therapy.

Conclusions:

  • Microgravity offers unique advantages for biological research and therapeutic applications.
  • Further investigation into microgravity's role in cell-based therapies, especially for neurological conditions, is warranted.