Related Experiment Video

Updated: Feb 8, 2026

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
10:35

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Use of apatinib combined with pemetrexed for advanced ovarian cancer: A case report

Huiting Sun1, Min Xiao, Sufen Liu

  • 1Department of Gynaecology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou Cancer Hospital, Soochow University, Changzhou, China.

Medicine
|July 7, 2018
PubMed
Abstract

Insights

Apatinib, an antiangiogenesis drug, shows potential in treating advanced ovarian cancer, particularly after chemotherapy failure. Further research is needed to confirm its efficacy and role in ovarian cancer therapy.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Ovarian cancer is a leading cause of gynecologic cancer deaths, posing significant therapeutic challenges.
  • Apatinib is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2 (VEGFR-2).

Observation:

  • A case study involved a 75-year-old woman with advanced ovarian high-grade serous papillary adenocarcinoma.
  • The patient received multiple lines of chemotherapy and subsequently apatinib therapy.

Findings:

  • Apatinib, as an antiangiogenesis drug, was administered to a patient with refractory ovarian cancer.
  • The study suggests apatinib may prolong survival in advanced ovarian cancer patients, alone or in combination.

Implications:

  • Apatinib could be a viable treatment option for advanced ovarian cancer post-chemotherapy or other targeted therapies.
  • Further clinical studies are essential to establish the definitive role of apatinib in advanced ovarian cancer management.

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