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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
The appropriate management algorithm for diabetic foot: A single-center retrospective study over 12 years
Jung Woo Chang1, Woong Heo, Matthew Seung Suk Choi
1Department of Plastic and Reconstructive Surgery, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
Diabetic foot management requires a phased approach, addressing infection and vascularity. Successful treatment, including revascularization and infection control, significantly reduces revision surgery rates.
Area of Science:
- Reconstructive surgery
- Diabetic foot management
- Vascular surgery
Background:
- Diabetic foot presents challenges due to poor circulation and chronic infection.
- Maximizing viable tissue is crucial, but amputation is sometimes unavoidable.
- A phased management approach is essential for effective diabetic foot care.
Purpose of the Study:
- To introduce an optimal algorithm for diabetic foot management.
- Analyze over 12 years of patient cases to refine treatment strategies.
- Provide a comprehensive yet accessible treatment algorithm for successful outcomes.
Main Methods:
- Reviewed 274 diabetic foot patients (2005-2017).
- Implemented a 5-step management process: evaluation, wound prep, vascularity improvement, surgery/dressing, and rehabilitation.
- Utilized microbial cultures, vascular studies, osteomyelitis assessment, debridement, negative-pressure wound therapy, and revascularization techniques.
Main Results:
- 81% of patients had confirmed infections.
- 83.8% of vascular studies revealed arterial occlusion.
- Revision surgery rates were lower (20.6%) with complete infection eradication compared to remnant infection (40.9%).
- Successful revascularization correlated with lower revision rates (21.3%) versus no/unsuccessful revascularization (28.2%).
Conclusions:
- Diabetic foot is a complex, multifactorial disease.
- A comprehensive treatment algorithm is vital for successful diabetic foot management.
- The proposed algorithm offers a significant approach to optimizing patient outcomes.
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