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Jin Tao, Min Jiang, Lu-ying Chen

    Yao Xue Xue Bao = Acta Pharmaceutica Sinica
    |July 7, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Traditional Chinese Medicine (TCM) flavor theory, particularly sweetish (Gan) and bitter (Ku) tastes, effectively regulates glucose and lipid metabolism in diabetes. Network pharmacology reveals key components and pathways, offering new strategies for TCM diabetes therapy.

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    Area of Science:

    • Pharmacology and Traditional Chinese Medicine (TCM)
    • Systems Biology and Network Pharmacology
    • Metabolic Disease Research

    Background:

    • The property and flavor theory of TCM is fundamental to clinical practice but lacks detailed chemical and biological characterization.
    • Understanding the molecular mechanisms underlying TCM prescriptions for conditions like 'Xiaoke' (diabetes) is crucial for validating therapeutic principles.

    Purpose of the Study:

    • To explore the prescription regularity and molecular mechanisms of flavor composition in TCM for diabetes therapy using network pharmacology.
    • To identify core paired-components and elucidate the drug-compound-target-pathway-function relationships.

    Main Methods:

    • Construction of a 'Xiaoke' prescription database for diabetes therapy.
    • Application of network pharmacology integrating ChEMBL, CTD, and KEGG databases.

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  • Analysis of 'drug-compound-target-pathway-function' relationships to understand flavor mechanisms.

    • Main Results:

    • Sweetish (Gan) and bitter (Ku) tastes were identified as popular therapeutic flavors for regulating glucose and lipid metabolism.
    • Key components like saponins (from Gan) and flavonoids/alkaloids (from Ku) were linked to improved insulin secretion, resistance, glucose utilization, and inflammation regulation.
    • Identified pathways include MAPK, PI3K-Akt, and PPAR, highlighting multi-target and multi-pathway therapeutic actions.

    Conclusions:

    • The study provides a preliminary summary of TCM's therapeutic mechanism for 'Xiaoke', involving anti-inflammation, immunoregulation, glucolipid metabolism adjustment, and insulin utilization improvement.
    • TCM therapy for 'Xiaoke' is demonstrated to be comprehensive, acting through multiple pathways.
    • This research offers a novel methodological approach for investigating TCM mechanisms in diabetes treatment.