[Antibody-dependent cell-mediated cytotoxicity of peripheral blood neutrophils in vitro in acute leukemia]

A study was made of in vitro antibody-dependent cellular cytotoxicity of neutrophils of peripheral blood in 14 cases of acute myeloblastic leukemia and in 20 healthy patients (control group). A decrease in the number of neutrophils, carrying receptors to Fc-IgG and to C3b-component of complement was registered compared to the results obtained for healthy people. Besides, the number of cells restoring Nitro-blue tetrazolium and myeloperoxidase activity decreased. The decrease in antibody-dependent cellular cytotoxicity of neutrophils in the cases of acute myeloblastic leukaemia is explained by the deficiency of the cell receptor apparatus and by the decrease in the intracellular metabolism in them.