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Updated: Feb 8, 2026

Optical Control of Living Cells Electrical Activity by Conjugated Polymers
Published on: January 28, 2016
Photoactive Oligo( p-phenylenevinylene) Functionalized with Phospholipid Units for Control and Visualization of
Yanyan Chen1,2, Lingyun Zhou1,2, Jianwu Wang1,2
1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry , Chinese Academy of Sciences , Beijing 100190 , P. R. China.
Abstract:
To take advantage of the excellent optical properties of conjugated polymers (CPs) or conjugated oligomers (COs) for biological applications, there is still a requirement to find new ways to deliver these conjugated molecular materials into cells in a facile, controllable, and noninvasive manner. Herein, a photoactive oligo( p-phenylenevinylene) (OPV) derivative was covalently attached with phospholipid units (OPV-lipid) to enhance its dispersion in water and facilitate its internalization by cells. OPV-lipid could be delivered into either the cell membrane or cytoplasm controllably through the assistance of liposomes with different formulas. It could also act as a fluorescent probe for cell imaging and visualization of the delivery process. This work shows a good potential for delivering functional conjugated molecular materials into cells in a controllable way.
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