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Reliable Method for Assessing Seed Germination, Dormancy, and Mortality under Field Conditions
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Airflow Obstruction Categorization Methods and Mortality.

Matthew J Hegewald1,2, Dave S Collingridge1, Thomas W DeCato1,2

  • 11 Intermountain Medical Center, Murray, Utah; and.

Annals of the American Thoracic Society
|July 7, 2018
PubMed
Summary
This summary is machine-generated.

Forced expiratory volume in 1 second (FEV1) % predicted best predicts 5-year survival in patients with airflow obstruction. This finding supports current guidelines recommending FEV1 % predicted for severity categorization.

Keywords:
airflow obstructionpulmonary function testingspirometry

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Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology
  • Clinical Epidemiology

Background:

  • Current guidelines use FEV1 % predicted to classify airflow obstruction severity.
  • This method has limitations, including demographic bias and failure to account for lung size.

Purpose of the Study:

  • To compare different methods for categorizing airflow obstruction severity.
  • To identify the method most strongly associated with mortality.

Main Methods:

  • Compared four methods: FEV1 % predicted, FEV1 % predicted adjusted by FVC % predicted, FEV1/FVC confidence interval, and FEV1 z-scores.
  • Utilized receiver operating characteristic curve analysis to assess 5-year survival prediction.
  • Analyzed data from 2,000 patients aged 40-80 with airflow obstruction.

Main Results:

  • Significant differences in severity categorization were observed across methods.
  • FEV1 % predicted and FEV1 z-scores categorized more patients as severely obstructed.
  • FEV1 % predicted demonstrated the strongest association with 5-year survival.

Conclusions:

  • FEV1 % predicted is the most effective method for categorizing airflow obstruction severity regarding mortality prediction.
  • This validates current clinical practice and guideline recommendations.