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Updated: Feb 8, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
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Multi-Modal Pain Control in Ambulatory Hand Surgery.

Ryan K Harrison, Teresa DiMeo, Ryan D Klinefelter

  • 1The Ohio State University Wexner Medical Center, Department of Orthopaedics, Columbus, OH. Hisham.Awan@osumc.edu.

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A specific medication regimen combining oxycodone, acetaminophen, and ketorolac effectively reduced postoperative pain and narcotic use after hand surgery. This combination demonstrated fewer complications compared to other opioid-based pain management strategies.

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Area of Science:

  • Orthopedics
  • Pain Management
  • Pharmacology

Background:

  • Postoperative pain control is crucial for patient recovery after hand and wrist surgery.
  • Optimizing pain management while minimizing opioid reliance is a significant clinical challenge.

Purpose of the Study:

  • To evaluate the efficacy of different medication regimens in controlling postoperative pain and narcotic usage.
  • To compare pain scores, opioid consumption, and complication rates across various treatment groups.

Main Methods:

  • A prospective, randomized study involving 79 patients undergoing thumb carpometacarpal (CMC) arthroplasty or distal radius open reduction and internal fixation (ORIF).
  • Patients were assigned to one of four groups receiving specific combinations and dosing of oxycodone, acetaminophen, OxyContin, and ketorolac.
  • Pain levels, opioid usage, and complications were monitored for five days post-surgery.

Main Results:

  • While not statistically significant, the group receiving oxycodone, acetaminophen, and ketorolac showed lower overall pain scores, reduced opioid usage, and fewer complications.
  • This combination regimen appeared most effective in managing pain and side effects.

Conclusions:

  • A specific dosing regimen of oxycodone, acetaminophen, and ketorolac may offer superior postoperative pain control for ambulatory hand and wrist surgery.
  • This multimodal approach could lead to fewer complications and reduced opioid dependence.