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Updated: Feb 8, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
A Bifunctional MOF Catalyst Containing Metal-Phosphine and Lewis Acidic Active Sites
Ram R R Prasad1, Daniel M Dawson1, Paul A Cox2
1EaStCHEM School of Chemistry, University of St Andrews, Purdie Building, North Haugh, St Andrews, KY16 9ST, UK.
Abstract:
Post-synthetic modification of the hafnium metal-organic framework MOF-808(Hf) to include triarylphosphine ligands is reported. Sulfonated phenylphosphines are incorporated without oxidation to give a "MOF ligand" that can complex late transition metals such as Ir and Rh to give a bifunctional catalyst containing both metal-phosphine complexes and the Lewis acidic framework hafnium metal sites. The metallated phosphine-bearing MOFs act as fully heterogeneous bifunctional catalysts for tandem reductive amination and hydroaminomethylation reactions.
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