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Conjunctival Commensal Isolation and Identification in Mice
Published on: May 1, 2021
Nanofibrillar Patches of Commensal Skin Bacteria
Karine Glinel1,2, Adam Behrens2, Robert S Langer2
1Institute of Condensed Matter and Nanosciences , Université Catholique de Louvain , Croix du Sud 1/L7.04.02 , Louvain-la-Neuve , 1348 , Belgium.
Abstract:
We demonstrate entrapment of the commensal skin bacteria Staphylococcus epidermidis in mats composed of soft nanotubes made by membrane-templated layer-by-layer (LbL) assembly. When cultured in broth, the resulting nanofibrillar patches efficiently delay the escape of bacteria and their planktonic growth, while displaying high steady-state metabolic activity. Additionally, the material properties and metabolic activity can be further tuned by postprocessing the patches with additional polysaccharide LbL layers. These patches offer a promising methodology for the fabrication of bacterial skin dressings for the treatment of skin dysbiosis while preventing adverse effects due to bacterial proliferation.
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