Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Double-Stapled Peptide Scan Yields Potent Fusion Inhibitors of Respiratory Syncytial Virus.

Journal of medicinal chemistry·2026

Same author

Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses.

Cell chemical biology·2022

Same author

High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression.

Journal of virology·2022

Same author

Atopic Neutrophils Prevent Postviral Airway Disease.

Journal of immunology (Baltimore, Md. : 1950)·2021

Same author

Nonsegmented Negative-Sense RNA Viruses Utilize <i>N</i><sup>6</sup>-Methyladenosine (m<sup>6</sup>A) as a Common Strategy To Evade Host Innate Immunity.

Journal of virology·2021

Same author

NCoR1 fine-tunes type-I IFN response in cDC1 dendritic cells by directly regulating Myd88-IRF7 axis under TLR9.

European journal of immunology·2020

Search research articles

Related Experiment Video

Updated: Feb 8, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

UntRIG(er)ing lncRNAs.

Dominique Garcin¹

¹Department of Microbiology and Molecular Medicine, Centre Médical Universitaire, 1 rue Michel Servet, 1211, Geneva 4, Switzerland.

|July 7, 2018

Summary

A newly discovered long non-coding RNA, lnc-Lsm3b, acts as a decoy to prevent further activation of RIG-I (retinoic acid-inducible gene I) during viral infection. This finding offers insights into innate immune regulation.

Area of Science:

Immunology
Molecular Biology
RNA Biology

Background:

Type I interferons (IFN) are crucial for antiviral defense.
RIG-I (retinoic acid-inducible gene I) is a key pattern recognition receptor in the innate immune system.
Long non-coding RNAs (lncRNAs) are emerging as important regulators of cellular processes.

Purpose of the Study:

To investigate the role of lnc-Lsm3b in the innate immune response to viral infection.
To elucidate the mechanism by which lnc-Lsm3b modulates RIG-I activation.

Main Methods:

Analysis of lnc-Lsm3b expression in mouse macrophages during viral infection.
Biochemical assays to assess the interaction between lnc-Lsm3b and RIG-I.
Functional studies to determine the impact of lnc-Lsm3b on RIG-I signaling.

More Related Videos

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

Related Experiment Videos

Last Updated: Feb 8, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

Main Results:

lnc-Lsm3b is a long non-coding RNA induced by type I IFN late in infection.
lnc-Lsm3b directly binds to RIG-I, acting as a decoy molecule.
lnc-Lsm3b inhibits further activation of RIG-I, thereby dampening the immune response.

Conclusions:

lnc-Lsm3b plays a regulatory role in the innate immune system by controlling RIG-I activation.
This lncRNA acts as a negative feedback mechanism to prevent excessive inflammation.
lnc-Lsm3b represents a potential target for therapeutic intervention in viral infections.