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Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols
Yuchao Zhu1, Kaimeng Huang1, Jun Pan1
1State Key Laboratory of Natural and Biomimetic Drugs, Peking University, 100191, Beijing, China.
Abstract:
Aliphatic alcohols are common and bulk chemicals in organic synthesis. The site-selective functionalization of non-activated aliphatic alcohols is attractive but challenging. Herein, we report a silver-catalyzed δ-selective Csp3-H bond functionalization of abundant and inexpensive aliphatic alcohols. Valuable oximonitrile substituted alcohols are easily obtained by using well-designed sulphonyl reagents under simple and mild conditions. This protocol realizes the challenging δ-selective C-C bond formation of simple alkanols.
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