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Updated: Feb 8, 2026

Dorsal Root Ganglia Isolation and Primary Culture to Study Neurotransmitter Release
Published on: October 6, 2018
Pathways of CGRP Release from Primary Sensory Neurons
Francesco De Logu1, Romina Nassini1, Lorenzo Landini1
1Department of Health Sciences, Section of Clinical Pharmacology and Oncology, Headache Center, University of Florence, Florence, Italy.
Small molecule antagonists targeting calcitonin gene-related peptide (CGRP) receptors show promise for treating migraines. Understanding CGRP release mechanisms is key to developing new migraine therapies.
Area of Science:
- Neuroscience
- Pharmacology
- Pain Research
Background:
- Calcitonin gene-related peptide (CGRP) release from trigeminal neurons is implicated in migraine pathophysiology.
- Small molecule antagonists and monoclonal antibodies targeting CGRP pathways have demonstrated clinical benefits.
Purpose of the Study:
- To explore the role of CGRP release in migraine headaches.
- To investigate potential therapeutic targets for migraine treatment by understanding CGRP secretion pathways.
Main Methods:
- Review of clinical trial data for CGRP antagonists.
- Analysis of studies on ion channels and receptors involved in CGRP release.
- Examination of intracellular pathways regulating CGRP secretion.
Main Results:
- CGRP release from sensory neurons is a key mechanism in migraine.
- Excitatory pathways triggering CGRP release may provoke migraines.
- Inhibitory pathways modulating CGRP release show potential as antimigraine treatments.
Conclusions:
- Targeting CGRP pathways offers a promising therapeutic strategy for migraines.
- Further research into intracellular mechanisms of CGRP secretion is crucial for effective migraine treatment.
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