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Related Experiment Video

Updated: Feb 8, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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Age-associated changes in waking hippocampal sharp-wave ripples.

Stephen L Cowen1,2,3, Daniel T Gray1,2, Jean-Paul L Wiegand1,2

  • 1Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, Arizona, 85724.

Hippocampus
|July 8, 2018
PubMed
Summary
This summary is machine-generated.

Aging alters waking sharp-wave ripples (SW ripples), important for memory. Aged rats showed more ripples but a lower rate, with frequency changes during behavior, potentially compensating for memory decline.

Keywords:
oscillationreactivationworking memory

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Aging Research

Background:

  • Sharp-wave ripples (SW ripples) are crucial for memory consolidation during sleep and retrieval during wakefulness.
  • Normal aging reduces sleep-related SW ripple frequency and occurrence, potentially impacting memory.
  • The effects of aging on waking SW ripples remain largely unexplored.

Purpose of the Study:

  • To investigate age-dependent changes in the characteristics of hippocampal sharp-wave ripples during waking behavior.
  • To compare waking SW ripple activity between young and aged rats performing a memory-related task.

Main Methods:

  • Recorded CA1 hippocampal sharp-wave ripples in young and aged F344 male rats during a place-dependent eyeblink conditioning task.
  • Analyzed ripple rate, frequency, and occurrence in relation to behavioral states (track running, reward consumption, rest).

Main Results:

  • Aged rats exhibited more waking ripples overall, but a lower ripple rate when accounting for time spent in locations, likely due to reduced locomotor activity.
  • Young rats showed increased ripple rates near rewards, an effect absent in aged rats.
  • While ripple frequency was lower in aged rats at rest, it increased during behavior to levels comparable to young rats.

Conclusions:

  • Aging alters waking sharp-wave ripple dynamics, characterized by increased occurrence but decreased rate, potentially linked to reduced movement.
  • The compensatory increase in ripple frequency during behavior in aged rats may help mitigate age-related memory deficits.
  • Waking ripple characteristics during behavior may not be directly modulated by eyeblink conditioning itself.