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Targeting corneal inflammation by gene therapy: Emerging strategies for keratitis

Josune Torrecilla1, Ana Del Pozo-Rodríguez1, Mónica Vicente-Pascual1

  • 1Pharmacokinetic, Nanotechnology and Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, Centro de investigación Lascaray ikergunea, University of the Basque Country UPV/EHU, Paseo de la Universidad 7, Vitoria-Gasteiz, Spain.

Experimental Eye Research
|July 8, 2018
PubMed

Insights

Gene therapy offers a promising approach for treating corneal inflammation (keratitis) and neovascularization, addressing limitations of current treatments. Research is advancing, focusing on delivery systems and cytokine regulation for ocular surface diseases.

Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Gene Therapy

Background:

  • Corneal inflammation (keratitis) and neovascularization are significant ocular surface diseases.
  • Current treatments for keratitis are limited by efficacy, side effects, and short action duration.

Purpose of the Study:

  • To review the progress and challenges of gene therapy for corneal inflammation.
  • To explore gene therapy's potential for treating ocular surface inflammatory conditions.

Main Methods:

  • Discussion of inflammation processes in the cornea.
  • Overview of viral and non-viral nucleic acid delivery systems.
  • Analysis of therapeutic strategies targeting neovascularization and cytokine regulation.

Main Results:

  • Gene therapy shows potential for treating corneal inflammation and neovascularization.
  • Experimental gene therapies for ocular disorders are emerging with encouraging clinical trial results.

Conclusions:

  • Gene therapy represents a developing frontier for managing corneal inflammation.
  • Further research into delivery systems and molecular targets is crucial for clinical translation.
Keywords:
AngiogenesisCorneal inflammationCorneal neovascularizationGene editingGene therapyKeratitisNon-viral vectorsViral-vectors

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