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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Obesity01:24

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys
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Obesity and Kidney Disease.

Jay I Lakkis1, Mathew R Weir2

  • 1University of Hawaii John A. Burns School of Medicine, 95 Maui Lani Pkwy, Wailuku, HI 96793-2416.

Progress in Cardiovascular Diseases
|July 8, 2018
PubMed
Summary

Obesity, a global epidemic, involves metabolic dysfunction and inflammation, significantly impacting kidney health. This review explores the complex links between obesity and chronic kidney disease, including shared risk factors and therapeutic strategies.

Keywords:
AdiponectinChronic kidney diseaseLeptinMetabolic syndromeMetabolically-healthy obesityObesityObesity-related hypertension

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Area of Science:

  • Endocrinology
  • Nephrology
  • Metabolic Diseases

Background:

  • Obesity is a systemic disease of white adipose tissue, reaching epidemic proportions globally.
  • It is characterized by hormonal (adipokine) imbalances, metabolic dysregulation, inflammation, and target organ damage.
  • Obesity phenotypes vary, with metabolically unhealthy obesity often linked to metabolic syndrome.

Purpose of the Study:

  • To review the complex, bidirectional links between obesity and chronic kidney disease (CKD).
  • To elucidate shared pathophysiological pathways and risk factors contributing to both conditions.
  • To summarize current non-pharmacological and pharmacological therapeutic strategies for obesity-related CKD.

Main Methods:

  • Literature review of studies investigating the relationship between obesity and kidney disease.
  • Analysis of shared mechanisms including inflammation, oxidative stress, and hyperinsulinemia.
  • Synthesis of clinical manifestations and therapeutic approaches.

Main Results:

  • Obesity and CKD share numerous complex, multi-layered links.
  • Common pathways include chronic inflammation, oxidative stress, and hyperinsulinemia.
  • Associated risk factors like insulin resistance, hypertension, and dyslipidemia contribute to both.

Conclusions:

  • The relationship between obesity and CKD is intricate, involving shared detrimental pathways.
  • Understanding these links is crucial for managing patients with both conditions.
  • Comprehensive therapeutic strategies are needed to address obesity-related kidney damage.