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Photostimulation by Femtosecond Laser Activates Extracellular-signal-regulated Kinase ERK Signaling or Mitochondrial Events in Target Cells
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Photostimulation by Femtosecond Laser Activates Extracellular-signal-regulated Kinase ERK Signaling or Mitochondrial Events in Target Cells

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Targeting ERK signaling pathway by polyphenols as novel therapeutic strategy for neurodegeneration

Mohammad Hosein Farzaei1, Devesh Tewari2, Saeideh Momtaz3

  • 1Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|July 8, 2018
PubMed

Insights

Natural bioflavonoids, potent antioxidants, combat neurodegeneration by scavenging free radicals. These compounds modulate the extracellular-signal-regulated kinase (ERK) pathway, offering therapeutic potential for neurological disorders and aging.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Nutritional Science

Background:

  • Oxidative stress contributes to neurodegeneration and aging.
  • Dietary antioxidants, particularly flavonoids, show promise in preventing neurological decline.
  • Natural products offer anti-amyloid effects and are available as nutraceuticals.

Purpose of the Study:

  • To summarize the effects of natural bioflavonoids on the extracellular-signal-regulated kinase (ERK) signaling pathway.
  • To explore the molecular mechanisms underlying the neuroprotective functions of dietary flavonoids.
  • To highlight the therapeutic potential of natural antioxidants in combating neurodegenerative diseases.

Main Methods:

  • Literature review of studies on natural bioflavonoids and neuroprotection.
  • Analysis of research focusing on the modulation of the ERK signaling pathway by flavonoids.
  • Examination of the anti-amyloid and radical scavenging properties of dietary antioxidants.

Main Results:

  • Natural phenolic compounds, including flavonoids, are effective radical scavengers.
  • Bioflavonoids modulate various components of the ERK signaling pathway.
  • Flavonoids derived from dietary sources exhibit protective effects against neurodegenerative diseases.

Conclusions:

  • Natural bioflavonoids represent a promising therapeutic strategy for neurodegenerative diseases and aging.
  • Modulation of the ERK pathway is a key mechanism for the neuroprotective effects of flavonoids.
  • The safe and non-toxic nature of natural antioxidants makes them attractive for neural health improvement.
Keywords:
ERKFlavonoidsMAPKMEK/ERKNatural productsNeurodegenerative diseases

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