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Transient Passovoy defect during a febrile illness.
American Journal of Hematology
|November 1, 1985
Summary
A rare bleeding disorder, the Passovoy defect, was transiently acquired by a patient during a febrile illness. This acquired hemorrhagic diathesis resolved spontaneously, suggesting infection or medication as potential causes.
Area of Science:
- Hematology
- Infectious Diseases
- Pharmacology
Background:
- The Passovoy defect is a recently identified hemorrhagic diathesis.
- Acquired bleeding disorders can arise from various underlying conditions.
Observation:
- A patient presented with a febrile illness, potentially linked to Epstein-Barr virus (EBV).
- During this illness, the patient transiently developed the Passovoy defect.
Findings:
- Standard coagulation tests, including prothrombin time and assays for factors VIII, IX, XI, XII, prekallikrein, and high molecular weight kininogen, were normal.
- No specific circulating inhibitor was identified.
- The acquired Passovoy defect resolved spontaneously.
Implications:
- This case suggests that infectious processes, such as EBV infection, may trigger transient hemorrhagic diatheses.
- Sulfisoxazole medication is also considered a potential contributing factor to the acquired Passovoy defect.
- Further research is needed to elucidate the mechanisms behind transiently acquired bleeding disorders.