Related Experiment Video

Updated: Feb 8, 2026

Murine Renal Transplantation Procedure
18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

30.7K

Coronary artery disease in renal transplant recipients: an angiographic study

Ioannis A Paizis1, Polyxeni D Mantzouratou1, Georgios S Tzanis1

  • 1Cardiology Department, General Hospital of Athens "Laiko", Athens, Greece.

Hellenic Journal of Cardiology : HJC = Hellenike Kardiologike Epitheorese
|July 9, 2018
PubMed

Insights

Coronary artery disease (CAD) is less severe in renal transplant recipients (RT) than in dialysis patients, despite longer end-stage renal disease (ESRD) duration. However, coronary artery calcification is common post-transplant, with successful percutaneous coronary intervention (PCI) in RT.

Area of Science:

  • Cardiology
  • Nephrology
  • Transplantation

Background:

  • Cardiovascular disease (CVD) is the primary cause of death in renal transplant recipients (RT).
  • Coronary artery disease (CAD) in RT patients remains understudied.
  • Understanding CAD in RT is crucial for improving patient outcomes.

Purpose of the Study:

  • To compare the severity and extent of CAD in RT patients versus those with end-stage renal disease (ESRD) on dialysis and healthy controls.
  • To assess the prevalence of coronary artery calcification in these groups.
  • To evaluate the success rate of percutaneous coronary intervention (PCI) in RT patients.

Main Methods:

  • A comparative angiographic study involving 50 RT patients, 50 ESRD dialysis patients, and 50 healthy controls from 2012-2017.
  • Patients were matched for age, gender, diabetes, and angiography indication.
  • Coronary artery disease (CAD) severity was quantified using the SYNTAX score; calcified lesions and PCI success rates were also assessed.

Main Results:

  • Renal transplant recipients (RT) had less severe CAD (mean SYNTAX score 13.3) compared to dialysis patients (20.6) but more than controls (9.4).
  • Coronary artery calcification was highly prevalent in RT (75.7%) and dialysis patients (92.1%) versus controls (15.8%).
  • Percutaneous coronary intervention (PCI) demonstrated a high success rate (93.8%) in RT patients.

Conclusions:

  • Despite longer end-stage renal disease (ESRD) duration, renal transplant recipients (RT) exhibit less severe coronary artery disease (CAD) than dialysis patients.
  • High prevalence of coronary artery calcification necessitates vigilance in RT patients.
  • Percutaneous coronary intervention (PCI) is a safe and effective treatment option for CAD in RT patients.
Abstract

Keywords:
Coronary artery calcificationCoronary artery diseaseEnd-stage renal diseaseKidney transplantation

More Related Videos

Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease09:06

Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease

Published on: November 28, 2012

11.4K
A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection06:59

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

Published on: February 2, 2022

4.5K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.1K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
500
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
289
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
399
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
703
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
387