Angiotensin converting enzyme in semen and its possible role in capacitation

Angiotensin Converting Enzyme (ACE) is present in the testis, epididymis and semen. But no physiological role has been assigned to ACE. The present study is to indicate possible role of ACE in capacitation. Semen was incubated in minimum capacitation in vitro. Epinephrine and serotonin were added to note the effect of biogenic amines. The leakage of ACE was very high in capacitated spermatozoa compared to spermatozoa in saline. Presence of amines in the saline induced ACE leakage. These results indicate that ACE may be involved in the capacitation.