Related Experiment Video

Updated: Feb 8, 2026

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

2.6K

Angiotensin-related genetic determinants of cardiovascular disease in patients undergoing hemodialysis

Sharon M Moe1,2, Jin Long3, Tae-Hwi Linus Schwantes-An4

  • 1Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|July 9, 2018
PubMed

Insights

Genetic variants in AGTR1 and ACE influence cardiovascular mortality in dialysis patients. The AGTR1 rs5186 C allele is linked to increased cardiovascular events and death in European and African ancestry groups.

Area of Science:

  • Cardiovascular genetics
  • Renal medicine
  • Pharmacogenomics

Background:

  • Cardiovascular mortality is high in dialysis patients.
  • Ancestry differences in outcomes suggest genetic factors.
  • Secondary hyperparathyroidism is common in hemodialysis patients.

Purpose of the Study:

  • Investigate genetic associations with cardiovascular mortality in dialysis patients.
  • Analyze single-nucleotide polymorphisms (SNPs) in AGTR1 and ACE genes.
  • Conduct a meta-analysis across European and African ancestry groups.

Main Methods:

  • DNA samples from the EVOLVE trial (cinacalcet vs. placebo) were analyzed.
  • SNPs in angiotensin-converting enzyme receptor type I (AGTR1) and angiotensin-converting enzyme (ACE) genes were genotyped.
  • Survival analyses were performed separately for European Ancestry (EA) and African Ancestry (AfAn) populations, followed by meta-analysis.

Main Results:

  • Meta-analysis revealed significant association of AGTR1 rs5186 with increased rates (25-34%) of the primary composite endpoint, all-cause mortality, cardiovascular mortality, and heart failure (P < 0.001).
  • Three ACE SNPs were linked to reduced sudden cardiac death (SCD) rates in EA.
  • One ACE SNP (rs4318) was associated with lower SCD rates in AfAn.

Conclusions:

  • The AGTR1 rs5186 C allele is associated with higher mortality and major cardiovascular events in EA and AfAn patients with end-stage kidney disease.
  • ACE gene variants show associations with sudden cardiac death in dialysis patients.
Abstract

Keywords:
angiotensincardiovascular mortalitygeneticshemodialysisrenin–angiotensin–aldosterone system

More Related Videos

In Silico Clinical Trials for Cardiovascular Disease09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.8K

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
577
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
1.8K
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
80.3K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
895
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
937
Genetics of Speciation02:16

Genetics of Speciation

Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.7K