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Published on: January 30, 2020
E. coli strain engineering for the production of advanced biopharmaceutical products
Tania Selas Castiñeiras1, Steven G Williams1, Antony G Hitchcock1
1Cobra Biologics, Stephenson Building, The Science Park, Keele ST5 5SP, UK.
Abstract:
Since the emergence of the biopharmaceutical industry in the 1980's, Escherichia coli, has played an important role in the industrial production of recombinant proteins and plasmid DNA for therapeutic use. Currently, advanced biopharmaceutical products, including rationally designed recombinant proteins and viral-vector gene therapies, offer unprecedented promise for the long-term management, and even cure of disease. As such, E. coli remains an important production host for the biopharmaceutical industry. This review provides insight into the industrially relevant strain engineering approaches used to enhance both the quantity and quality of these therapeutic products.
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