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Preventive Effects of Renin-angiotensin System Inhibitors on Oxaliplatin-induced Peripheral Neuropathy: A

Mami Uchida1, Hitoshi Kawazoe2, Shingo Takatori1

  • 1Department of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime, Japan.

Clinical Therapeutics
|July 10, 2018
PubMed
Abstract

Insights

Renin-angiotensin system (RAS) inhibitors may prevent oxaliplatin-induced peripheral neuropathy. This study found a significantly lower incidence of neurotoxicity in patients treated with RAS inhibitors compared to those not receiving them.

Area of Science:

  • Oncology
  • Neuroscience
  • Pharmacology

Background:

  • Oxaliplatin is a key chemotherapy agent, but its use is limited by induced peripheral neuropathy.
  • The renin-angiotensin system (RAS) is implicated in various cellular processes, and its inhibition is explored for therapeutic benefits.

Purpose of the Study:

  • To investigate the potential preventive effect of RAS inhibitors on oxaliplatin-induced peripheral neuropathy.
  • To clarify the association between RAS inhibitor use and the incidence of neurotoxicity in cancer patients receiving oxaliplatin.

Main Methods:

  • Retrospective observational study analyzing electronic medical records of 150 cancer patients treated with oxaliplatin.
  • Comparison of peripheral neuropathy incidence between patients treated with and without RAS inhibitors.
  • Multivariate Cox proportional hazards model used to identify risk factors for neurotoxicity.

Main Results:

  • The incidence of severe peripheral neuropathy was 36.9% in the RAS inhibitor group versus 91.7% in the non-RAS inhibitor group.
  • RAS inhibitor use was associated with a decreased risk of neurotoxicity (adjusted hazard ratio, 0.42; P=0.048).

Conclusions:

  • RAS inhibitors demonstrate a potential preventive effect against oxaliplatin-induced peripheral neuropathy.
  • These findings suggest a novel therapeutic strategy to mitigate chemotherapy-related side effects.
Keywords:
angiotensin receptor blockerangiotensin-converting enzyme inhibitorchemotherapy-induced peripheral neuropathyoxaliplatinrenin-angiotensin system inhibitors

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