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An Immune System-Modified Rat Model for Human Stem Cell Transplantation Research

Xinglong Yang1, Jianlong Zhou1, Jingjin He2

  • 1Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.

Stem Cell Reports
|July 10, 2018
PubMed
Summary

A new NSG-like (NSGL) rat model improves human stem cell research by enabling better engraftment of human cells and immune system reconstitution. This xenotransplantation model offers advantages for preclinical studies.

Keywords:
acquired immunityhematopoietic stem cellshuman stem cellsimmunodeficient rat modelsinnate immunity

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