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Micro-/nano-sized delivery systems of ginsenosides for improved systemic bioavailability
Hyeongmin Kim1, Jong Hyuk Lee2, Jee Eun Kim3
1College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
Journal of Ginseng Research
|July 10, 2018
Summary
Ginsenosides from ginseng have limited use due to poor bioavailability. Micro- and nano-sized delivery systems show promise in enhancing ginsenoside absorption and therapeutic potential.
Area of Science:
- Pharmacology
- Natural Products Chemistry
- Nanotechnology
Background:
- Ginsenosides, derived from ginseng, are natural compounds with diverse pharmacological activities.
- Their therapeutic application is hindered by low bioavailability, stemming from poor solubility, membrane permeability, and stability.
- Extensive metabolism further reduces the efficacy of orally administered ginsenosides.
Purpose of the Study:
- To review micro- and nano-sized delivery systems for enhancing ginsenoside bioavailability.
- To provide comprehensive information for developing improved delivery strategies.
- To maximize the therapeutic potential of ginsenosides.
Main Methods:
- Review of literature on micro-/nano-sized delivery systems for ginsenosides.
- Analysis of systems including emulsions, polymeric particles, and vesicular systems.
- Evaluation of how these systems impact solubility, permeability, and stability.
Main Results:
- Micro-/nano-sized delivery systems significantly improve ginsenoside bioavailability.
- Enhanced solubility, permeability, and stability were observed with these systems.
- Various delivery platforms demonstrate potential for overcoming bioavailability challenges.
Conclusions:
- Micro-/nano-delivery systems are effective in overcoming the bioavailability limitations of ginsenosides.
- These advanced delivery strategies are crucial for unlocking the full therapeutic value of ginseng compounds.
- Further research in designing optimized delivery systems is warranted to maximize ginsenoside efficacy.
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