First literature review of carbapenem-resistant Providencia
1Pharmaceutical Care Services, Riyadh, Saudi Arabia.
New Microbes and New Infections
|July 10, 2018
Abstract:
Providencia species are Gram-negative bacteria that belong to the Enterobacteriaceae family. They have intrinsic resistance to colistin and tigecycline, which makes treatment of the multidrug-resistant strains of Providencia challenging. Carbapenem-resistant Providencia species are increasingly reported. In this review, patients' characteristics, resistance mechanisms, treatment and infection control measures of carbapenem-resistant Providencia species in the literature are described.
Insights
Carbapenem-resistant Providencia species, Gram-negative bacteria, pose treatment challenges due to existing resistance. This review details patient data, resistance, and management strategies for these difficult-to-treat infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Providencia species are Gram-negative bacteria within the Enterobacteriaceae family.
- These bacteria exhibit intrinsic resistance to colistin and tigecycline, complicating treatment options.
- The emergence of carbapenem-resistant Providencia species presents a growing clinical concern.
Purpose of the Study:
- To review and synthesize existing literature on carbapenem-resistant Providencia species.
- To describe the characteristics of patients infected with these resistant strains.
- To outline known resistance mechanisms, treatment approaches, and infection control measures.
Main Methods:
- Literature review of studies reporting carbapenem-resistant Providencia species.
- Analysis of patient demographics, clinical presentations, and outcomes.
- Compilation of data on antimicrobial susceptibility, resistance genes, and therapeutic interventions.
Main Results:
- Increasing reports of carbapenem-resistant Providencia infections globally.
- Identification of various resistance mechanisms contributing to carbapenem resistance.
- Summary of treatment outcomes with different antimicrobial agents and supportive care.
Conclusions:
- Carbapenem-resistant Providencia species represent a significant threat due to limited treatment options.
- Effective infection control and prompt diagnosis are crucial for managing outbreaks.
- Further research is needed to develop novel therapeutic strategies against these resistant pathogens.
Related Concept Videos
01:10Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
01:13Review and Preview
11.5K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.5K
01:22Resistivity
4.6K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
01:19Resistance
6.0K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K
01:16Equivalent Resistance
991
In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
991
01:25Resistance and Conductance
518
A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
518