Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

577
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
577
Overview of the Cardiovascular System01:14

Overview of the Cardiovascular System

12.0K
The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
12.0K
Biological Effects of Radiation02:59

Biological Effects of Radiation

18.0K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.0K
Aging01:26

Aging

714
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
714
What is Conservation Biology?01:57

What is Conservation Biology?

24.4K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.4K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

4.1K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Why next-generation mechanistic models will transform drug discovery: integrating efficacy and safety.

Expert opinion on drug discovery·2026
Same author

Psychobiotics in Mental Health - Between Hope, Evidence, and the Need for Precision.

Alpha psychiatry·2026
Same author

Antimicrobial Residues in a Key Cerrado River: Distribution, Persistence, and Effects on Zebrafish Embryo-Larval Development.

Environmental toxicology·2026
Same author

Insights Into Bifenthrin Stereoisomers and Their Regulatory Implications.

ChemistryOpen·2026
Same author

Acute Effects of High-Intensity Interval Training (HIIT) on Heart Rate Variability and Psychoaffective Responses Among Bipolar Patients and their Control Peers: A Randomized Crossover Trial.

CNS & neurological disorders drug targets·2026
Same author

Liraglutide and Exenatide in Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Cognitive Outcomes.

Pharmaceutics·2026

Related Experiment Video

Updated: Feb 8, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K

Aging-Induced Biological Changes and Cardiovascular Diseases.

James Oluwagbamigbe Fajemiroye1,2,3, Luiz Carlos da Cunha2, Roberto Saavedra-Rodríguez4

  • 1Biological Sciences Institute, Federal University of Goiás, Goiânia, GO, Brazil.

Biomed Research International
|July 10, 2018
PubMed
Summary

Aging impairs cardiovascular function and increases cardiovascular disease (CVD) risk. Understanding age-related changes in the heart and blood vessels is key to developing new CVD therapies.

More Related Videos

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

5.8K
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.7K

Related Experiment Videos

Last Updated: Feb 8, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K
Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

5.8K
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.7K

Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Molecular Biology

Background:

  • Aging is associated with a decline in physiological regulation and cellular functions.
  • This decline is linked to an increased risk and incidence of cardiovascular diseases (CVDs).

Purpose of the Study:

  • To review the biological alterations during aging that contribute to cardiovascular diseases.
  • To explore the mechanisms linking aging to CVDs, including structural, functional, and molecular changes.

Main Methods:

  • Review of existing literature on aging and cardiovascular disease.
  • Analysis of aging-induced structural, biochemical, and functional modifications in the cardiovascular system.
  • Examination of autonomic nervous system (ANS) dysregulation in aging.
  • Investigation of epigenetic alterations and their role in CVD development.
  • Assessment of the impact of aging on atherosclerosis and stroke.

Main Results:

  • Aging leads to structural and biochemical changes in the heart and vasculature, including stiffening and deposition of collagen and calcium.
  • Autonomic nervous system (ANS) dysregulation and cardiomyocyte loss impair cardiovascular homeostasis and function.
  • Epigenetic alterations accumulate with age, contributing to CVD pathogenesis.
  • Aging processes are implicated in the development of atherosclerosis and stroke.

Conclusions:

  • Aging-induced cardiovascular alterations significantly increase the risk of CVDs.
  • Understanding these age-related changes offers potential for improved CVD diagnosis and targeted therapies.
  • Further research into aging mechanisms can lead to novel therapeutic strategies for cardiovascular conditions.