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The Role of Microparticles in Rheumatic Diseases and their Potentials as Therapeutic Tools

Wen-Hai Shao1

  • 1Division of Immunology, Allergy and Rheumatology, University of Cincinnati, Medical Science Building, Room 7410, 231 Albert Sabin Way, Cincinnati OH 45267, USA.

Journal of Molecular Immunology
|July 10, 2018
PubMed

Insights

Microparticles (MPs), tiny cell fragments involved in cell communication, can be immunotolerogenic or immunogenic. Elevated MPs are linked to rheumatic diseases, suggesting roles in pathogenesis and therapy.

Area of Science:

  • Immunology
  • Cell Biology
  • Rheumatology

Background:

  • Microparticles (MPs) are crucial for intercellular communication, influencing cell adhesion, signal transduction, activation, and apoptosis.
  • MPs exert diverse biological effects on immune responses, with their immunogenicity dependent on content and composition.
  • Increased MP levels are observed in various rheumatic diseases.

Purpose of the Study:

  • To review the immunopathogenic roles of MPs in rheumatic diseases.
  • To explore the therapeutic potential of MPs in managing rheumatic conditions.

Main Methods:

  • Literature review of studies on microparticles and rheumatic diseases.
  • Analysis of the immunomodulatory functions of MPs.
  • Synthesis of current knowledge on MP involvement in rheumatic disease pathogenesis.

Main Results:

  • MPs can act as either immunotolerogenic or immunogenic factors.
  • The composition and content of MPs dictate their immune effects.
  • Elevated MP levels are a common finding across different rheumatic diseases.

Conclusions:

  • MPs are implicated in the pathogenesis of rheumatic diseases.
  • MPs represent a potential therapeutic target for rheumatic conditions.
Keywords:
BiomarkerMicroparticlesRASLE

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