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Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
Histological changes secondary to wire coil placement in breast tissue and lymph nodes
Ignacio Pinilla-Pagnon1, Belén Pérez-Mies1,2, María Eugenia Reguero1,2
1Pathology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Abstract:
We describe the histological and immunohistochemical features of the changes produced by spiral coil localization wires in the breast parenchyma and lymph nodes of a total of 100 patients undergoing surgery for different breast lesions. Coil wires produced cystic lesions containing a hyaline, mucous-like, PAS-negative fluid. Cavities were lined by cells of variable morphology ranging from synovial-like cells (with a conspicuous epithelial appearance) to mononuclear or multinucleate histiocytic cells that expressed CD68, but were negative for keratins. CD3-positive/CD8-positive T lymphocytes predominated in the inflammatory reaction. Pathologists should be aware of these changes in order to differentiate coil-related lesions from other granulomatous or epithelial lesions, including mucocele-like and ductal carcinoma in situ lesions.
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