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The interphase interval within a bipolar nanosecond electric pulse modulates bipolar cancellation
Chris M Valdez1, Ronald Barnes1, Caleb C Roth1
1Radio Frequency Bioeffects Branch, Bioeffects Division, Airman Systems Directorate, 711th Human Performance Wing, Air Force Research Laboratory, JBSA Fort Sam Houston, Texas.
Bioelectromagnetics
|July 10, 2018
Summary
Nanosecond electric pulse (nsEP) bipolar cancellation (BPC) effects were studied. A 10 microsecond interphase interval resolved BPC in symmetrical nsEPs, while asymmetrical nsEPs required longer intervals, suggesting membrane recovery is key.
Area of Science:
- Bioelectromagnetics
- Cellular Electrophysiology
Background:
- Nanosecond electric pulse (nsEP) exposure induces physiological effects.
- Bipolar (BP) nsEP exposure can lead to reduced membrane perturbation, known as bipolar cancellation (BPC).
- Previous studies suggest membrane recovery, influenced by interphase intervals, is a factor in BPC.
Purpose of the Study:
- To investigate the impact of interphase intervals on BPC in symmetrical and asymmetrical BP nsEPs.
- To explore interphase intervals beyond 50 microseconds for BP nsEPs.
- To refine the conceptual model of BPC as a balance between membrane charging and discharging events.
Main Methods:
- Surveyed various interphase intervals for symmetrical and asymmetrical BP nsEPs.
- Monitored YO-PRO-1 uptake as an indicator of membrane perturbation.
- Compared BPC resolution between different nsEP configurations and intervals.
Main Results:
- A 10 microsecond interphase interval resolved BPC in symmetrical 600 ns + 600 ns and 900 ns + 900 ns nsEPs.
- Asymmetrical BP nsEPs (e.g., 300 ns + 900 ns) required longer interphase intervals (<10 ms) to resolve BPC compared to symmetrical nsEPs.
- Findings support the role of membrane recovery in BPC.
Conclusions:
- Interphase interval duration is critical for resolving BPC in nsEPs.
- Symmetrical and asymmetrical BP nsEPs exhibit different interphase interval requirements for BPC resolution.
- The conceptual model of BPC involving localized membrane charging and discharging is supported and extended.
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