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Updated: Feb 8, 2026

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HFIP-Assisted C-H Functionalization by Cp*CoIII : Access to Key Reactive Cobaltacycles and Implication in Catalysis
Jesús Sanjosé-Orduna1,2, Juan Manuel Sarria Toro1, Mónica H Pérez-Temprano1
1Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology (BIST), Avgda. Països Catalans 16, 43007, Tarragona, Spain.
Abstract:
Described here is a synthetic approach to access two of the most widely invoked cationic cobaltacycles in Cp*CoIII -catalyzed C-H functionalization reactions by C-H activation. The unique stabilizing capability of MeCN was used to surmount the previously proposed reversible nature of the C-H metalation step. Moreover, it is revealed the boosting effect of 1,1,1,3,3,3-hexafluoroisopropanol in the metalation step and in the reaction between N-pyrimidinylindole and diphenylacetylene under catalytic conditions.
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