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[Modification of radiosensitivity and the cyclic AMP system].

Iu Iu Chirkov, M A Malatsidze

    Nauchnye Doklady Vysshei Shkoly. Biologicheskie Nauki
    |January 1, 1985
    PubMed
    Summary

    Cyclic AMP (adenosine monophosphate) plays a key role in modifying cellular radiosensitivity and mediating radioprotective effects. Catecholamines require beta-adrenergic receptors and the cAMP system for their radioprotective potential.

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    [Conditions of activation of guanylate cyclase from human platelets].

    Biokhimiia (Moscow, Russia)·1988

    Area of Science:

    • Radiobiology
    • Molecular Endocrinology
    • Biochemistry

    Context:

    • Cyclic AMP (adenosine monophosphate) is a crucial second messenger involved in numerous cellular processes.
    • Radiosensitivity of biological objects can be modulated by various factors, including chemical agents.
    • Radioprotective agents are used to mitigate the harmful effects of ionizing radiation.

    Purpose:

    • To summarize experimental findings on the role of cyclic AMP in radiosensitivity.
    • To elucidate the involvement of the cyclic AMP system in the action of radioprotective compounds.
    • To investigate the mechanisms underlying the radioprotective effects of catecholamines, particularly in mammalian cells.

    Summary:

    • This review consolidates research on how cyclic AMP influences biological object radiosensitivity and mediates radioprotection.
    • It examines the impact of radioprotectors on cellular cyclic AMP levels and the activity of associated proteins.
    • Evidence suggests that beta-adrenergic receptors and their coupled cyclic AMP system are essential for catecholamine-induced radioprotection in vitro.

    Impact:

    • Highlights the critical role of the cyclic AMP pathway in cellular responses to radiation.
    • Provides insights into the molecular mechanisms of radioprotection by catecholamines.
    • Discusses methodological considerations for interpreting radiobiological experiment results within biochemical and endocrinological frameworks.

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