Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary optic neuropathy in Behçet's syndrome.

Qinglin Yang1, Lin Sun1, Qian Wang1

  • 1Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|July 10, 2018
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunoadsorption and subsequent immunoglobulin G replacement (IA/IG) in patients with dilated cardiomyopathy: a systematic review and meta-analysis.

Frontiers in cardiovascular medicine·2026
Same author

A lifespan pooled analysis of 832 cases: characterizing the lifespan profile of clinical presentations and comorbidities in congenital pulmonary airway malformation.

Orphanet journal of rare diseases·2026
Same author

A Case of Optic Neuritis with Glial Fibrillary Acidic Protein Antibody and Secondary Ophthalmoplegia.

Neuro-ophthalmology (Aeolus Press)·2026
Same author

Prognostic value of the triglyceride-glucose index combined with glycemic variability for all-cause mortality in patients with sepsis: A retrospective cohort study.

Science progress·2026
Same author

Hybrid SU(1,1) Interferometry in Optomechanics.

Physical review letters·2026
Same author

<i>In vivo</i> immune engineering via mRNA therapeutics: reprogramming the post-infarction cardiac microenvironment.

Frontiers in immunology·2026

Primary optic neuropathy in Behçet's syndrome (PONBS) often affects females and may present with a unique MRI "sunflower-like" sign. Males face a significantly higher risk of severe visual loss from this condition.

Area of Science:

  • Ophthalmology
  • Neurology
  • Rheumatology

Background:

  • Primary optic neuropathy in Behçet's syndrome (PONBS) is rare, with limited case reports.
  • Behçet's syndrome is a multisystem inflammatory disease.

Purpose of the Study:

  • To characterize the clinical presentation, MRI findings, and visual outcomes of PONBS.
  • To identify risk factors for visual loss in PONBS.

Main Methods:

  • Retrospective evaluation of 61 patients with first-onset optic neuritis meeting International Criteria for Behçet's Disease (ICBD).
  • Analysis of clinical features, MRI findings (optic nerve signal and perineural enhancement), and visual prognosis.
  • Kaplan-Meier survival analysis to estimate visual loss risk.
Keywords:
Behçet’s syndromeInternational Criteria for Behçet’s DiseaseOptic neuropathySunflower-like signclinical featuremagnetic resonance imagingoptic neuritisprognosis

Related Experiment Videos

Main Results:

  • Female predominance (1.7:1 ratio) and isolated optic neuropathy were common.
  • Perineural enhancement around the orbital optic nerve (68.7%) and a sunflower-like MRI sign (71.7%) were frequent findings.
  • Males had a significantly higher cumulative risk of severe visual loss (62.5% vs. 14.7% in females at 24 months).

Conclusions:

  • PONBS often presents as isolated optic neuropathy, particularly in females, with a potential distinctive MRI sunflower sign.
  • Short-term recurrence of PONBS is uncommon.
  • Males are at a substantially higher risk for severe visual impairment in PONBS.