Related Experiment Video
Updated: Feb 8, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
Systematic Review and Meta-Analysis of Selected Cancers in Petroleum Refinery Workers
A Robert Schnatter1, Min Chen, Elizabeth A DeVilbiss
1Occupational and Public Health Division, ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey (Dr Schnatter, Dr Chen, Dr Lewis, Ms Gallagher); Drexel University, Philadelphia, Pennsylvania (Dr DeVilbiss).
Objective:
We studied the risk of 11 cancers of a priori interest in petroleum refinery workers.
Methods:
Iterative searches identified 36 studies for the 11 cancer sites. Statistical heterogeneity and publication bias were assessed to enhance interpretation of meta-relative risks.
Results:
Statistical heterogeneity was marked for mesothelioma, but was largely due to study quality. Higher quality studies showed a meta-relative risk (RR) of 3.22, (95% prediction interval 1.45 to 7.23). Melanoma (meta-RR = 1.23) and acute lymphoid leukemia (meta-RR = 1.51), showed results consistent with higher risk, but both were driven by one or two studies. Eight other cancer outcomes showed summary meta-RR's consistent with unity.
Conclusions:
Most cancer outcomes are consistent with background risk in refinery workers. This work has clarified an excess mesothelioma risk, conditional on study quality stratification. Continued surveillance is warranted for melanoma and ALL.
More Related Videos
08:36Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
06:26Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
Published on: November 27, 2019
Related Concept Videos
Review and Preview
Percentiles are a type of fractile that partition data into...
Review and Preview
Random and Systematic Errors
Directing Effect of Substituents: meta-Directing Groups
Cancer Survival Analysis
Systematic Sampling Method
Systematic sampling is one of the simplest methods...